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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Ann Hum Genet. 2012 Nov 6;77(1):31–46. doi: 10.1111/j.1469-1809.2012.00734.x

Table 4.

Anorectal atresia and the interaction between MKKS SNPs in the offspring and maternal pre-pregnancy obesitya

Cases
(N)		 Controls
(N)		 MKKS
rs2013178 TT
genotype
in offspring		 Maternal
pre-
pregnancy
obesityb 		Odds ratio
(95% confidence
interval)c 		Interaction
contrast ratio
(95% confidence
interval)de
All subjects
42 182 No No Ref 0.59 (−0.27, 1.90)
25 81 Yes No 1.29 (0.73, 2.29)
P=0.39
4 49 No Yes 0.38 (0.12, 1.18)
P=0.094
8 26 Yes Yes 1.69 (0.68, 4.16)
P=0.26
Non-Hispanic white
29 151 No No Ref 0.49 (−1.14, 3.05)
20 49 Yes No 2.15 (1.11, 4.15)
P=0.023
3 39 No Yes 0.43 (0.13, 1.52)
P=0.15
7 16 Yes Yes 2.37 (0.89, 6.33)
P=0.085
MKKS
rs1003994 GG
genotype
in offspring
All subjects
38 162 No No Ref 0.60 (−0.20, 1.80)
29 103 Yes No 1.20 (0.68, 2.11)
P=0.54
2 43 No Yes 0.26 (0.06, 1.16)
P=0.078
10 32 Yes Yes 1.49 (0.64, 3.50)
P=0.36
Non-Hispanic white
27 140 No No Ref 0.66 (−0.79, 3.21)
22 62 Yes No 1.80 (0.94, 3.43)
P=0.076
2 37 No Yes 0.30 (0.07, 1.35)
P=0.10
8 18 Yes Yes 2.45 (0.95, 6.31)
P=0.063
a

Analyses included 79 cases and 340 controls that had data available on maternal pre-pregnancy body mass index and other covariates used in the regression analyses

b

Maternal pre-pregnancy body mass index ≥30 kg/m2

c

Logistic regression models adjusted for parity and maternal smoking; models that included all subjects were also adjusted for maternal race/ethnicity

d

As described by Richardson & Kaufman (2009), the interaction contrast ratio was calculated from the product term for interaction in a linear odds ratio model; confidence intervals were based on the likelihood ratio

e

Models for calculation of the interaction contrast ratio and 95% confidence interval were adjusted for parity and maternal smoking; models that included all subjects were also adjusted for maternal race/ethnicity