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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Immunobiology. 2012 Jul 27;218(4):561–569. doi: 10.1016/j.imbio.2012.07.022

Figure 1. Atherosclerotic lesion areas in apoE-KO and DKO mice treated with LPS.

Figure 1

(A) Representative histology of the atherosclerotic lesions from apoE-KO and apoE-KO/CD1d-KO (DKO) mice treated with LPS or PBS. Arrows represent the oil red O-positive, atherosclerotic lesions typically observed within the internal lamina (original magnification, x40). (B) Mean lesion areas of apoE-KO and DKO mice treated with LPS or PBS. Number of mice: apoE-KO: PBS; n= 9, apoE-KO: LPS; n= 9; DKO: PBS; n= 10, DKO: LPS; n= 8. Each symbol represents the mean lesion area of an individual mouse. Horizontal bars represent the mean of all mice in each group, and vertical bars represent SE. Statistical analyses were performed with Mann-Whitney U test. (C) Representative immunohistochemistry of the atherosclerotic lesions from apoE-KO mice administered LPS (right) or PBS (left). Arrows represent atherosclerotic lesions typically observed within the internal lamina (original magnification, × 40 and × 200). Oil red O (ORO) (top), hematoxylin-eosin (HE) (middle) and elastica-Masson staining (EM) (bottom) were performed in each group.