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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Immunobiology. 2012 Jul 27;218(4):561–569. doi: 10.1016/j.imbio.2012.07.022

Fig. 6. Schematic representation of the relationship between exacerbation of atherosclerotic lesions by microbial lipids and activation of NKT cells by microbial lipids.

Fig. 6

NKT cells may aggravate the lesion development of atherosclerosis via soluble or cellular factors produced in response to direct activation by pathogen-derived glycolipids (represented by α-GalCer) or indirect activation by LPS via recognition of self-derived glycolipids in the presence of CD1d.