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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Cancer Lett. 2012 Oct 27;329(1):68–73. doi: 10.1016/j.canlet.2012.10.022

Fig. 2.

Fig. 2

Metastatic development following intraosseous inoculation of TBJ neuroblastoma or CT26 colon carcinoma cells into the BM. a Liver tumors did not develop in A/J mice inoculated s.c. (i) with 200,000 TBJ cells while metastatic liver tumors did develop in mice injected either i.v. (ii) or i.o. (iii) with only 50,000 TBJ cells. b Lung tumors did not develop in mice inoculated s.c. with 200,000 CT26 cells while several tumors developed in the lungs of mice injected either i.v. (ii) or i.o. (iii) with only 50,000 CT26 cells. c In the same CT26-inoculated mice (b), metastatic liver tumors did not develop in either s.c. (i) or i.v. (ii) inoculated mice, but they did develop in i.o. inoculated mice (iii). All sections were blotted with Ki67 and counterstained with Harris' Hemotoxylin. All field-of-views are representative of sections from all mice in each group (n=3), the larger panels are 10× magnification, and the insets are 4× magnification.