. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Hum Mutat. 2012 Oct 11;34(1):191–199. doi: 10.1002/humu.22210

Table 2.

Computational predictions of HARS variant pathogenicity

Variant	MUPro¹	PolyPhen²	PolyPhen2³	SIFT⁴
p.Ala5Glu	0.20	0.34	0.00	1.00
p.Arg137Gln	−1.00^†	2.46^†	1.00^†	0.00^†
p.Gly205Asp	0.00	0.71	0.28	0.00^†
p.Val238Ala	−1.00^†	1.90^†	0.78	0.00^†
p.Lys376Arg	0.48	1.41	0.01	0.31
p.Pro505Ser	−.99^†	2.01^†	0.31	0.00^†

MUPro scores <0 indicate a decrease in protein stability

PolyPhen scores ≥1.5 indicate a prediction of “pathogenic”

PolyPhen2 scores ~1 indicate a prediction of “pathogenic”

⁴

SIFT scores ≤0.05 indicate a prediction of “pathogenic”

^†

Denotes a “pathogenic” prediction