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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: NMR Biomed. 2012 Jul 5;26(1):35–42. doi: 10.1002/nbm.2816

Figure 1.

Figure 1

(A) In vivo NMR spectrum of inducible Her2/neu mammary tumor acquired with STEAM sequence. Large peak at 1.3 ppm presents unresolved signals from lipids and lactate. In vivo lactate spectra acquired with HadSelMQC pulse sequence of orthotopic (B) and inducible (C) Her2/neu transgenic mammary tumors. The lactate level in the inducible model was lower and less reproducible than that of the orthotopic model. (C) Quantitation of in vivo data. (D) Concentration of lactate in tumor PCA extracts of orthotopic and inducible transgenic models. The same high concentration of lactate was found in both tumor models ex vivo. Errors bars are the standard deviation of 7 and 5 experiments respectively.