Table 2.
Baseline Characteristics of Younger (Age 18–64) and Older (Age ≥65) Adult Lung Transplantation Recipients
| VARIABLE | YOUNGER COHORT (n=4031) | OLDER COHORT (n=774) | P value |
|---|---|---|---|
| Age (years) | 55.0 (45.0,60.0) | 67.0 (65.0,69.0) | <0.0001 |
| Female | 1758 (43.6) | 246 (31.8) | <0.0001 |
| White | 3363 (83.4) | 695 (89.8) | <0.0001 |
| Greater than high school education (N miss=652) | 1816 (45.1) | 386 (49.9) | 0.0467 |
| Working for income | 705 (17.5) | 100 (12.9) | <0.0001 |
| LAS diagnosis group | |||
| Group A (obstructive lung disease) | 1627 (40.4) | 291 (37.6) | <0.0001 |
| Group B (pulmonary vascular disease) | 172 (4.3) | 20 (2.6) | |
| Group C (CF or immunodeficiency) | 617 (15.3) | 1 (0.1) | |
| Group D (restrictive lung disease) | 1495 (37.1) | 451 (58.3) | |
| Other | 120 (3.0) | 11 (1.4) | |
| Primary disease specific diagnosis | |||
| COPD/emphysema | 1209 (30.0) | 270 (34.9) | <0.0001 |
| Idiopathic pulmonary fibrosis | 1156 (28.7) | 419 (54.1) | |
| Other | 1666 (41.3) | 85 (11.0) | |
| %Predicted FEV, median | 29.0 (19.0,48.0) | 45.0 (27.0,62.0) | <0.0001 |
| %Predicted FVC, median | 45.0 (35.0,58.0) | 53.0 (41.0,65.0) | <0.0001 |
| Type of Lung Transplantation | |||
| Single | 1227 (30.4) | 486 (62.8) | <0.0001 |
| Double | 2804 (69.6) | 288 (37.2) | |
| Disability level (KPS at transplantation) | |||
| No assistance self-care (KPS 80–100) | 652 (16.2) | 127 (16.4) | 0.0149 |
| Minimal assistance self-care (KPS 50–70) | 2553 (63.3) | 523 (67.6) | |
| Full assistance self-care (KPS 10–40) | 826 (20.5) | 124 (16.0) | |
| BMI | 24.7 (20.8,28.3) | 26.1 (23.0,28.9) | <0.0001 |
| LAS at transplantation | 37.7 (33.7,45.0) | 39.0 (33.9,47.1) | 0.0138 |
| Days on waiting list | 87.0 (26.0,270.0) | 45.0 (16.0,135.0) | <0.0001 |
| Time to last follow-up or death (years) | 2.7 (1.7,3.9) | 2.0 (1.1,3.0) | <0.0001 |
Values are summarized as number (percent) or median (25th, 75th percentile) and P values were obtained using Wilcoxon Rank Sums (continuous) and chi square (categorical) tests.
Abbreviations: Lung Transplantation (LT), Cystic fibrosis (CF), Lung allocation Score (LAS), Chronic Obstructive Pulmonary Disease (COPD), Forced Vital Capacity (FVC), Forced Expiratory Volume (FEV), Karnofsky Performance Score (KPS).
These recipients survived to 11 months after Lung Transplantation and had available Karnofsky Performance Score reported thereafter.