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Comparison of the overall structure of dsDNA in the presence and absence of polyamide to the analogous sequence of dsRNA. a) X-ray structure (PDB: 3OMJ) of polyamide 3 complexed to the DNA sequence d(5'-CCAGTACTGG-3') solved at 0.95 Å.[16] Electron density map of the polyamide is contoured at the 1.0 σ level. b) Native DNA structure (PDB: 1D8G) d(5'-CCAGTACTGG-3') solved at ultrahigh resolution (0.74 Å) by Rees and coworkers.[21] c) Model of ideal A-form dsRNA for comparison.
