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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Ann Neurol. 2012 Oct 17;72(6):918–926. doi: 10.1002/ana.23693

Figure 1. Remyelination in Subpial Cortical Lesions.

Figure 1

Brains from control patients without neurological disease have dense PLP immunoreactivity in all cerebral cortical layers (Panel A). Many regions of cortex in patients with MS show a similar pattern in PLP immunoreactivity (Panel B). A subpial demyelinated lesion with complete loss of PLP immunoreactivity is shown in Panel C. Many subpial lesions are not completely demyelinated, but contain PLP-positive myelin internodes (Panels D and E). Frequently, these areas contain actively-myelinating oligodendrocytes with PLP-positive cell bodies and processes extending to myelin internodes (Panels D and E, arrowheads in insets). Actively-myelinating oligodendrocytes are most frequent in lesions where PLP-positive myelin occupied 60% or less of the lesion area (Panel F). The scale bar represents 400 μm for Panels A-E.