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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biol Cell. 2012 Dec 5;105(1):1–13. doi: 10.1111/boc.201200044

Figure 4. Sequence Conserved Differences within heterodimeric Kinesin-2 Motors.

Figure 4

Kif3a, Kif3b, and Kif3c show conserved sequence differences between themselves. Conserved differences within the microtubule binding region, particularly loop 11, and the neck linker suggests that these motors have evolved to have different microtubule binding interactions and to respond differently to tension within the neck linker. It is possible that these differences within the neck linker optimize the motors to work at the different vertical loads, and that differences within the microtubule binding region bias one motor to bind first to the microtubule. Sequences aligned using T-coffee server (Notredame et al., 2000), and further analyzed utilizing Jalview (Clamp et al., 2004; Waterhouse et al., 2009).