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. Author manuscript; available in PMC: 2014 Oct 22.
Published in final edited form as: Neuroscience. 2012 May 1;251:75–89. doi: 10.1016/j.neuroscience.2012.04.061

Figure 3.

Figure 3

A and B: Electron micrographs demonstrating changes in the spine apparatus morphology in peritumorous neocortical tissue from human patients. A – A large spine (Sp) forming a perforated asymmetric synapse with a bouton (B) contains a hypertrophic spine apparatus (asterisk). B – Another spine (Sp) containing a spine apparatus with dilated cisterns of smooth endoplasmic reticulum (asterisks). This spine forms an asymmetric synapse with a bouton (B) containing vesicles that appear to be disrupted. In both A and B, the dense plate of the spine apparatus appears to give rise to filamentous material (arrows) that contacts the base of PSD. Scale bars = 0.2 μm in A and B. Electron micrograph in A is from Spacek (1987).

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