Table 6.
Results of Cox regression analysis for local recurrence, distant metastases and survival.
| tested variables | cell types | cell types/ | TNM / | ||
| inflamm. | infiltrate | ||||
| RR | 95% CI | RR | 95% CI | ||
| local recurrence | peritumoral mast cells | ||||
| - none/few | 3.7 | 1.1 -12.8 | 1.9 | 0.5-7.1 | |
| -moderate | 1.3 | 0.4- 4.4 | 0.9 | 0.3-3.1 | |
| - many | 1.0 | 1.0 | |||
| inflammatory infiltrate | |||||
| -none/few | - | 1.0 | |||
| -extensive | 0.3 | 0.0-2.2 | |||
| n = 148 | TNM | ||||
| 33 events | - I/I I | - | 1.0 | ||
| -III/IV | 2.4 | 0.9-6.1 | |||
| distant | peritumoral mast cells | ||||
| metastases | - none/few | 4.5 | 1.6-12.2 | 2.5 | 1.2-5.8 |
| - moderate | 1.1 | 0.4-2.9 | 0.9 | 0.3-2.3 | |
| - many | 1.0 | 1.0 | |||
| intratumoral T cells (CD3) | |||||
| - none/few | 3.2 | 1.5-6.8 | 2.6 | 1.2-5.8 | |
| -moderate | 2.0 | 0.9-4.1 | 1.8 | 0.8-3.8 | |
| - many | 1.0 | 1.0 | |||
| inflammatory infiltrate | |||||
| - none/few | - | 1.0 | |||
| - extensive | 1.0 | 0.4-2.9 | |||
| n = 159 | TNM | ||||
| 65 events | -I/II | - | 1.0 | ||
| -III/IV | 4.4 | 1.9-9.9 | |||
| survival | peritumoral eosinophils | ||||
| - none/few | 3.6 | 1.5-8.7 | 3.0 | 1.2-7.2 | |
| -moderate | 2.8 | 1.2-6.6 | 2.1 | 0.9-5.1 | |
| - many | 1.0 | 1.0 | |||
| peritumoral mast cells | |||||
| - none/few | 2.9 | 1.2-6.8 | 1.4 | 0.6-3.4 | |
| -moderate | 0.8 | 0.4-1.9 | 0.6 | 0.3-1.4 | |
| - many | 1.0 | 1.0 | |||
| inflammatory infiltrate | |||||
| - none/few | - | 1.0 | |||
| - extensive | 1.0 | 0.4-2.5 | |||
| n = 136 | TNM | ||||
| 59 events | - I/II | - | 1.0 | ||
| - III/IV | 2.9 | 1.4-6.2 | |||
Cell types are included in the multivariate analysis if their p-value was less than 0.05 in the univariate analysis (table 3). Cell types are reported here and included in the multivariate analysis with TNM classification and inflammatory infiltrate, if they were significant in the Cox' regression of the cell types forward step-wise applied.