Fig. 2.

Conformational change in β6-α7 and MIDAS regions of TRAP VWA and integrin αI domains. The β6-α7 regions in closed and open conformations of TRAP VWA (A) and integrin αI (B) domains. Fragments are shown in identical orientations after superposition on the entire domain. Homologous Trp and Phe sidechains and the disulfide unique to TRAP are shown in a stick. The last ordered residue in the closed falciparum structure (K240) and its homolog in the open vivax structure (R236) are shown as Cα spheres. (C–F) MIDAS structures, with MIDAS residues shown in stick, metal ions as gold spheres, and waters as red spheres. Metal coordinations are dashed. Integrin αM subunit αI domains are from (23).