Table 4.
Estradiol transport across full-thickness pig skin in presence of AvD and AvG (n = 9)
| Donor compartment | Permeability × 10−3 , cm/h | Lag time, h | Enhancement factor |
| Estradiol | 2.27 ± 0.48 | 4.96 ± 2.75 | NA |
| Estradiol + 1 mg/mL AvD | 4.29 ± 1.26* | 5.93 ± 2.38 | 1.93 ± 0.50 |
| Estradiol + 1 mg/mL AvG | 4.19 ± 0.63* | 5.43 ± 2.05 | 1.89 ± 0.65 |
3H estradiol (saturated solution in PBS with radioactive tracer) was used for the transport studies. The enhancement factor is a comparison measure within each experiment, and it is the ratio of the permeability of estradiol in presence of Avs to its native permeability across SC. The average ± SD is reported. Estradiol applied with AvD or AvG was significantly more permeable than estradiol applied alone. Differences in lag time were not significant. NA, not applicable.
*P < 0.1.