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. 2012 Dec 10;109(52):21283–21288. doi: 10.1073/pnas.1200942109

Table 4.

Estradiol transport across full-thickness pig skin in presence of AvD and AvG (n = 9)

Donor compartment Permeability × 10−3 , cm/h Lag time, h Enhancement factor
Estradiol 2.27 ± 0.48 4.96 ± 2.75 NA
Estradiol + 1 mg/mL AvD 4.29 ± 1.26* 5.93 ± 2.38 1.93 ± 0.50
Estradiol + 1 mg/mL AvG 4.19 ± 0.63* 5.43 ± 2.05 1.89 ± 0.65

3H estradiol (saturated solution in PBS with radioactive tracer) was used for the transport studies. The enhancement factor is a comparison measure within each experiment, and it is the ratio of the permeability of estradiol in presence of Avs to its native permeability across SC. The average ± SD is reported. Estradiol applied with AvD or AvG was significantly more permeable than estradiol applied alone. Differences in lag time were not significant. NA, not applicable.

*P < 0.1.