Fig. 2.

Incidence and histology of benign tumors. (A) WT and Itga3 eKO mice develop at least one tumor with a diameter larger than 1 mm. In contrast, tumors with a diameter larger than 3 mm occur in virtually all WT but only in 25% of Itga3 eKO mice. (B) Proliferation is significantly diminished in papillomas of DMBA/TPA-treated Itga3 eKO mice compared with those of WT littermates. (Scale bars, 100 μm.) (Inset magnification, 5×; *P < 0.05.) (C) Histology of representative papillomas and keratoacanthomas. Tumors are histologically similar but are larger in WT mice than in Itga3 eKO mice. (Scale bars, 500 μm.)