Fig. 4.

Decreased renal function in Pkd1^V/V mice with Gpsm1 gene deficiency. Plasma was obtained from mice between P11 and P12 to measure the levels of either BUN (A) or creatinine (B) as a measure of renal function. (A) *P < 0.05 to P < 0.01: significant difference between Gpsm1^−/−;Pkd1^V/V and the other two Pkd1^V/V mouse groups. ^¶P < 0.05 to P < 0.001: higher significant difference between all Pkd1^V/V groups and both Pkd1^+/+ groups. (B) *P < 0.05: significant difference between noncystic Gpsm1^−/−;Pkd1^+/+ mice and the Pkd1^V/V groups. **P < 0.01: significant difference between Gpsm1^+/−;Pkd1^V/V and Gpsm1^−/−;Pkd1^V/V mice. The numbers for each distinct genotype are shown in the bars of each graph. ND, not determined.