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Effect of SPP inhibitors on P. yoelii liver-stage parasites
| Compound | Mean P. yoelli EEF IC50 ± SD, μM | HepG2 IC50, μM |
| Atovaquone | 0.0015 ± 0.00090 | >10 |
| NITD731 | 0.0078 ± 0.0018 | >10 |
| NITD679 | 0.047 ± 0.015 | >10 |
| LY-411575 | 0.048 ± 0.032 | >10 |
SPP inhibitor activity was assayed against P. yoelii sporozoites and host HepG2 cells. EEF, exo-erythrocytic form.
