Table 3.
Enriched KEGG non-metabolic pathways of the 17 key regulatory modules.
| Module name | KEGG pathway | P value |
|---|---|---|
| FOXO3_NM | 03050~Proteasome | 0.0342 |
| 05213~Endometrial cancer | 0.0213 | |
| 05223~Non-small cell lung cancer | 0.0221 | |
| TP53_NM | 04110~Cell cycle | 0.039 |
| 04115~p53 signaling pathway | 0.0212 | |
| 04210~Apoptosis | 0.027 | |
| 04310~Wnt signaling pathway | 0.0459 | |
| 04722~Neurotrophin signaling pathway | 0.0384 | |
| 05014~Amyotrophic lateral sclerosis (ALS) | 0.0163 | |
| 05210~Colorectal cancer | 0.0191 | |
| 05212~Pancreatic cancer | 0.0215 | |
| 05213~Endometrial cancer | 0.016 | |
| 05214~Glioma | 0.02 | |
| 05215~Prostate cancer | 0.0273 | |
| 05216~Thyroid cancer | 0.009 | |
| 05217~Basal cell carcinoma | 0.0169 | |
| 05218~Melanoma | 0.0218 | |
| 05219~Bladder cancer | 0.013 | |
| 05220~Chronic myeloid leukemia | 0.0224 | |
| 05222~Small cell lung cancer | 0.0258 | |
| 05223~Non-small cell lung cancer | 0.0166 | |
| hsa_miR_16_M | 04330~Notch signaling pathway | 0.024 |
| 04370~VEGF signaling pathway | 0.0386 | |
| 04662~B cell receptor signaling pathway | 0.0381 | |
| hsa_let_7e_M | 04210~Apoptosis | 0.0181 |
| 04722~Neurotrophin signaling pathway | 0.0258 | |
| hsa_miR_30a_M | 04140~Regulation of autophagy | 0.0425 |
| 04144~Endocytosis | 0.0264 | |
| STAT1_M | 03440~Homologous recombination | 0.0086 |
| 04062~Chemokine signaling pathway | 0.0385 | |
| 04620~Toll-like receptor signaling pathway | 0.0209 | |
| 04630~Jak-STAT signaling pathway | 0.0317 | |
| 05212~Pancreatic cancer | 0.0144 |
One-sided Fisher's Exact Test was used to test whether the genes in a module were significantly enriched in any KEGG non-metabolic pathways. Six modules (FOXO3_NM, TP53_NM, hsa_miR_16_M, hsa_miR_30a_M, hsa_let_7e_M, STAT1_M) of which the resultant p values less than 0.05 are included in this table.