Table 8.
Mouse phenotypes significantly associated with top candidate genes by ToppFun.
| Phenotype ID | Phenotype name | p-value | Terms in query | Terms in genome |
|---|---|---|---|---|
| MP:0009745 | Abnormal behavioral response to xenobiotic | 6.77 × 10-7 | 12 | 215 |
| MP:0002206 | Abnormal CNS synaptic transmission | 4.31 × 10-6 | 14 | 382 |
| MP:0003635 | Abnormal synaptic transmission | 3.57 × 10-5 | 14 | 450 |
| MP:0002062 | Abnormal conditioning behavior | 6.87 × 10-5 | 10 | 199 |
| MP:0002063 | Abnormal learning/memory/conditioning | 9.26 × 10-5 | 13 | 405 |
| MP:0002065 | Abnormal fear/anxiety-related behavior | 1.05 × 10-4 | 10 | 208 |
| MP:0001362 | Abnormal anxiety-related response | 3.59 × 10-4 | 9 | 179 |
| MP:0002572 | Abnormal emotion/affect behavior | 8.34 × 10-4 | 11 | 329 |
| MP:0001454 | Abnormal cued conditioning behavior | 1.41 × 10-3 | 6 | 66 |
| MP:0003633 | Abnormal nervous system physiology | 2.44 × 10-3 | 20 | 1333 |
| MP:0001399 | Hyperactivity | 2.57 × 10-3 | 9 | 226 |
| MP:0001363 | Increased anxiety-related response | 2.86 × 10-3 | 7 | 117 |
| MP:0009357 | Abnormal seizure response to inducing agent | 9.04 × 10-3 | 7 | 139 |
| MP:0001449 | Abnormal learning/memory | 1.22 × 10-2 | 10 | 349 |
| MP:0003088 | Abnormal prepulse inhibition | 1.45 × 10-2 | 5 | 57 |
| MP:0003313 | Abnormal locomotor activation | 1.46 × 10-2 | 13 | 630 |
| MP:0000950 | abnormal seizure response to pharmacological agent | 1.53 × 10-2 | 6 | 99 |
| MP:0002945 | Abnormal inhibitory postsynaptic currents | 1.58 × 10-2 | 5 | 58 |
| MP:0004008 | Abnormal GABA-mediated receptor currents | 2.85 × 10-2 | 3 | 11 |
| MP:0009747 | Impaired behavioral response to xenobiotic | 3.45 × 10-2 | 5 | 68 |
| MP:0004747 | Abnormal cochlear OHC afferent innervation pattern | 3.48 × 10-2 | 2 | 2 |