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Human conditions associated with altered CD19 expression
| CD19 upregulation | CD19 downregulation |
|---|---|
| Systemic sclerosis (MFI) | SLE (MFI) |
| SLE (CD19high B cells) | CD19 deficiency |
| CVID, HIV (CD19high B cells) | Heterozygous mutation in CD19 |
| BCR deficiency (CD19high B cells) | CD81 deficiency |
| Mutations in Bruton's tyrosine kinase |
BCR, B-cell receptor; CVID, common variable immunodeficiency; MFI, mean fluorescence intensity; SLE, systemic lupus erythematosus.
