Table 1.

Protection of immunized mice with or without wt Ad5 priming against a lethal-dose anthrax spore challenge^a

Group	No. of animals/group	Vector/buffer	Dose/animal	Ad5 priming	No. of survivors/no. of animals tested
1	12	AdtPA83hu + AdmInhAhu	High dose	–	12/12
2	12	A195 buffer	None	–	0/12
3	12	AdtPA83hu + AdmInhAhu	High dose	+	12/12
4	11b	AdtPA83hu + AdmInhAhu	Median dose	+	11/11
5	12	AdtPA83hu + AdmInhAhu	Low dose	+	12/12
6	12	AdmInhAhu	108 IFU	–	0/12
7	12	A195 buffer	None	+	0/12
8	12	Naive control	None	–	0/12

^aHigh dose, 10⁸ IFU of AdtPA83hu/mouse plus 5.4 × 10⁶ IFU of AdmInhAhu/mouse; median dose, 10⁷ IFU of AdtPA83hu/mouse plus 5.4 × 10⁵ IFU of AdmInhAhu/mouse; low dose, 10⁶ IFU of AdtPA83hu/mouse plus 5.4 × 10⁵ IFU of AdmInhAhu/mouse; none, no AdtPA83hu and AdmInhAhu treatment.

^bLost one animal without replacement.