Fig 1.

MPER peptides and MPER-CHEMS lipopeptides. (A) N-MPER and C-MPER contained the nominal epitopes of monoclonal antibodies 2F5 and 4E10, respectively, with additional flanking sequences previously reported to improve binding (43, 58). The C terminus is amended with a two-residue linker and a lysine for on-resin lipid conjugation. Residues that were modified with phospho or nitro groups are indicated with asterisks. (B) Lipopeptide structure denoting the peptide, linker, and cholesteryl hemisuccinate lipid anchor. FP, fusion protein; NHR, N-heptad region; CHR, C-heptad region; TM, transmembrance domain.