Table 1.
Demographic Data
| Negative Margin | Positive Margin | All Patients | P Value | |
|---|---|---|---|---|
| Number of patients (%) | 843 (72.7%) | 316 (27.3%) | 1159 (100.0%) | |
| Mean age, years (SDa) | 59.3 (6.5) | 59.2 (6.4) | 59.3 (6.5) | .987 |
| Mean BMI, kg/m2 (SDa) | 28.1 (7.2) | 28.0 (3.9) | 28.1 (6.4) | .693 |
| Mean preoperative PSAa, ng/mL (SDa) | 5.4 (2.8) | 7.4 (6.7) | 5.9 (4.4) | <.001 |
| Clinical Gleason score | .003 | |||
| ≤6 | 485 (76.6%) | 148 (23.4%) | 633 (100.0%) | |
| 7 | 295 (68.6%) | 135 (31.4%) | 430 (100.0%) | |
| 8–10 | 61 (64.9%) | 33 (35.1%) | 94 (100.0%) | |
| Clinical stage | .073 | |||
| cT1 | 588 (73.2%) | 215 (26.8%) | 803 (100.0%) | |
| cT2 | 246 (72.8%) | 92 (27.2%) | 338 (100.0%) | |
| cT3 | 7 (46.7%) | 8 (53.3%) | 15 (100.0%) | |
| Risk class (D’Amico) | <.001 | |||
| Low | 439 (77.0%) | 131 (23.0%) | 570 (100.0%) | |
| Intermediate | 329 (71.4%) | 132 (28.6%) | 461 (100.0%) | |
| High | 74 (58.3%) | 53 (41.7%) | 127 (100.0%) | |
| Pathologic Gleason score | <.001 | |||
| ≤6 | 294 (82.4%) | 63 (17.6%) | 357 (100.0%) | |
| 7 | 483 (69.1%) | 216 (30.9%) | 699 (100.0%) | |
| 8–10 | 60 (61.9%) | 37 (38.1%) | 97 (100.0%) | |
| Pathologic stage | <.001 | |||
| pT0–pT2N0M0 | 718 (79.9%) | 183 (20.3%) | 901 (100.0%) | |
| T3aN0M0 | 89 (46.8%) | 101 (53.2%) | 190 (100.0%) | |
| T3b and pT4N0M0 | 25 (50.0%) | 25 (50.0%) | 50 (100.0%) | |
| TxN1Mx (positive nodes) | 8 (53.3%) | 7 (46.7%) | 15 (100.0%) | |
| Mean follow-up, months (SDa) | 15.6 (13.0) | 16.5 (14.3) | 15.9(13.4) | .337 |
| Learning curve | .248 | |||
| First quartile | 201 (69.3%) | 89 (30.7%) | 290 (100%) | |
| Second quartile | 217 (74.8%) | 73 (25.2%) | 290 (100%) | |
| Third quartile | 219 (75.8%) | 70 24.2%) | 289 (100%) | |
| Fourth quartile | 206 (71.0%) | 84 (29.0%) | 290 (100%) | |
| Nerve sparing status | .672 | |||
| Bilateral nerve sparing | 564 (72.7%) | 212 (27.3%) | 776 (100%) | |
| Unilateral nerve sparing | 217 (73.8%) | 77 (26.2%) | 294 (100%) | |
| Non nerve sparing | 60 (69.0%) | 27 (31.0%) | 87 (100%) |
a
SD=standard deviation; BMI=body mass index; PSA=prostate-specific antigen.