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Pharmacokinetic parameters of S/GSK1265744 and etravirine
| Treatment (n = 12) | Geometric mean value for the parameter (CVb [%])a |
||||||
|---|---|---|---|---|---|---|---|
| S/GSK1265744 |
ETR |
||||||
| AUC0-τ (μg · h/ml) | Cmax (μg/ml) | Cτ (μg/ml) | Median (range) Tmax (h) | AUC0-τ (ng · h/ml) | Cmax (ng/ml) | Cτ (μg/ml) | |
| S/GSK1265744 | 183 (13) | 9.47 (11) | 6.50 (14) | 3.04 (2.00–12.00) | |||
| S/GSK1265744 plus ETR | 184 (9) | 9.83 (11) | 6.49 (12) | 4.00 (2.00–8.00) | 9,176 (25) | 975 (24) | 597 (28) |
CVb, between-subject coefficient of variation.
