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Antimycobacterial activity of ISO against M. tuberculosis strains harboring mutations within hadA or hadC
| Strain | ISO MIC99 (μg/ml)a |
|---|---|
| Wild type | 0.5–1 |
| MTTR3 (HadA_C61G) | >10 |
| MTTR6 (HadA_C61S) | >10 |
| MTTR2 (HadC_T123A) | 10 |
| MTTR18 (HadC_V85F) | >10 |
MIC99s were determined by dilution on 7H10 solid agar medium supplemented with OADC.
