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Percent of survival as a function of the anidulafungin AUC0–24/MEC ratio for voriconazole-susceptible and voriconazole-resistant A. fumigatus isolates. Increased voriconazole and anidulafungin exposure was required to obtain maximum efficacy in mice infected by the voriconazole-resistant isolate. The curve is the model fit with the Hill equation for each datum.
