Table 3.

Animal models of AfLT against various clinical Candida isolates^a

Reference	Candida strain	Model and catheter type	Group	AfLT	DOT	Catheter salvage rateb
P. K. Mukherjee et al. (64)	1 C. albicans strain (M61)	Rabbit CVC model (mean CFU reduction and SEM)	Group I	None (control)	7 days	0/7 (0)
			Group II	ABLC at 5 mg/ml for 4 h	7 days	6/6 (100)
			Group III	ABLC at 5 mg/ml for 8 h	7 days	6/6 (100)
M. K. Schinabeck et al. (65)	1 C. albicans strain (M61)	Rabbit CVC model (mean CFU reduction and SEM)	Group I	None (control)	8 h per day for 7 days	0/7 (0)
			Group II	L-AmB at 10 mg/ml	8 h per day for 7 days	7/7 (100)
			Group III	FLC at 10 mg/ml	8 h per day for 7 days	2/7 (28.6)
J. A. Shuford et al. (66)	1 C. albicans strain (IDRL-5319)	Rabbit CVC model (mean CFU reduction)	Group I	None (control)	7 days	0/16 (0)
			Group II	CAS at 6.67 mg/ml	7 days	16/16 (100)
			Group III	d-AmB at 3.33 mg/ml	7 days	13/16 (81.3)
A. L. Lazzell et al. (67)	1 C. albicans strain (SC5314)	Murine (precatheterized) CVC model (mean CFU, kidney CFU, and SEM)	Group I	None (control)	24 h	0/6 (0)
			Group II	CAS at 0.25 μg/ml	24 h	4/6 (66.7)c

^aCVC, central venous catheter; L-AmB, liposomal amphotericin B; ABLC, amphotericin B lipid complex.

^bThe catheter salvage rate is given as the number of animals in the group for which the catheters were sterilized/total number of animals in the group with the percentage shown in parentheses.

^cCAS reduced >99% kidney dissemination compared to the value for the control group.