Fig 4.

Simulations from the mathematical model relating the plasma area under the concentration-time curve (AUC) to residual fungal burden in the kidney (solid squares) or vitreous humor (solid circles) at the end of the experimental period. The stasis lines for the kidney and the vitreous humor are shown by the broken lines; these represent the fungal burden at the time that anidulafungin therapy is begun, 48 h after inoculation. The means ± standard deviations of the AUCs that develop in neonates/infants and children aged 2 to 17 are shown (open circles). An “average” adult patient receiving anidulafungin at 100 mg/day develops an AUC of approximately 105 mg · h/liter.