Table 1.
Model parameter means, medians, and standard deviations
| Parameter (units)a | Mean | Median | SD |
|---|---|---|---|
| SCL (liters/h) | 0.191 | 0.208 | 0.048 |
| Vc (liters) | 0.825 | 0.789 | 0.261 |
| kce (h−1) | 5.328 | 0.381 | 8.562 |
| kec (h−1) | 5.251 | 0.265 | 7.528 |
| kcp (h−1) | 5.165 | 3.549 | 4.394 |
| kpc (h−1) | 16.949 | 21.090 | 9.552 |
| Vbrain (liters) | 49.364 | 49.096 | 21.556 |
| Kgmax-eye (log10 CFU/g/h) | 0.080 | 0.070 | 0.029 |
| Hg-eye | 3.331 | 4.958 | 2.010 |
| C50g-eye (mg/liter) | 0.193 | 0.148 | 0.170 |
| POPMAX-eye (CFU/g) | 82,291 | 99,139 | 33,087 |
| Kkmax-eye (log10 CFU/g/h) | 0.651 | 0.380 | 0.623 |
| Hk-eye | 3.496 | 3.292 | 1.481 |
| C50k-eye (mg/liter) | 0.710 | 0.687 | 0.291 |
| Kgmax-kidney (log10 CFU/g/h) | 0.096 | 0.092 | 0.0282 |
| Hg-kidney | 4.258 | 4.951 | 1.325 |
| C50g-kidney (mg/liter) | 3.204 | 1.550 | 3.936 |
| POPMAX-kidney (CFU/g) | 49,984,300 | 84,269,040 | 47,137,700 |
| Kkmax-kidney (log10 CFU/g/h) | 0.563 | 0.585 | 0.207 |
| Hk-kidney | 3.018 | 4.064 | 1.481 |
| C50k-kidney (mg/liter) | 15.309 | 18.701 | 7.286 |
| Initial condition-eye (CFU/g) | 3 | 3 | 2 |
| Initial condition-kidney (CFU/g) | 1,061 | 573 | 1,036 |
SCL, clearance of anidulafungin from the central compartment; Vc and Veye, volumes of central compartment and vitreous humor, respectively; kcp, kpc, kce, and kec, first-order rate constants that connect the respective compartments; N, burden (organisms/gram vitreous humor or kidney) of Candida albicans, Kgmax, maximal rate of growth in the vitreous humor or kidney; POPMAX, theoretical maximal density within the vitreous humor or kidney; Hg, slope function for the suppression of growth in the vitreous humor or kidney; C50g, concentration of drug producing half-maximal suppression of growth; Kkmax, maximal rate of kill in the vitreous humor or kidney; Hk, slope functions for the fungal kill in the vitreous humor or kidney; C50k, concentration of drug in the vitreous humor or kidney where fungal kill is half maximal.