Table 4.

MICs of five antimicrobial agents for 109 pathogenic Leptospira isolates

Origin of isolates (n)	MIC90 (range) (μg/ml)a
	Penicillin G	Doxycycline	Cefotaxime	Ceftriaxone	Chloramphenicol
All origins (109)	0.064 (≤0.002–1)	0.19 (0.023–0.5)	0.047 (≤0.002–0.125)	0.5 (0.006–2)	2 (0.094–3)
Thailand (63)	0.047 (≤0.002–0.75)	0.19 (0.023–0.5)	0.032 (≤0.002–0.094)	0.38 (0.006–1)	2 (0.094–3)
Lao PDR (28)	0.094 (≤0.002–0.125)	0.25 (0.032–0.25)	0.047 (≤0.002–0.064)	0.5 (0.008–2)	1.5 (0.125–2)
Sri Lanka (9)	1 (0.006–1)	0.38 (0.047–0.38)	0.032 (0.003–0.032)	0.38 (0.012–0.38)	1.5 (0.094–1.5)
Othersb (9)	0.064 (≤0.002–0.064)	0.19 (0.047–0.19)	0.125 (≤0.002–0.125)	1.5 (0.047–1.5)	2 (0.25–2)

^aMIC values are given in units/ml for penicillin G.

^bOthers were reference isolates from Indonesia (4 isolates), China (1 isolate), Belgium (1 isolate), Japan (1 isolate), Denmark (1 isolate), and the United States (1 isolate).