Table 3.
In vitro activity of five antifungal agents against 50 clinical isolates of Rhodotorula species using the CLSI broth microdilution assay
| Rhodotorula species (no. of isolates) | Cell incubation period (h) | MIC (μg/ml) for indicated antifungal agenta |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMB |
CAS |
VRC |
PSC |
FLC |
||||||||||||
| MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | ||
| R. mucilaginosa (44) | 48 | 1 | 1 | 0.25–1 | 8 | 8 | 1–16 | 1 | 2 | 0.25–2 | 2 | 2 | 0.5–4 | 64 | >64 | ≥64 |
| 72 | 1 | 1 | 0.5–1 | 8 | 16 | 4–16 | 2 | 4 | 0.5–4 | 2 | 4 | 1–8 | 64 | >64 | ≥64 | |
| R. glutinis (2) | 48 | ND | ND | 0.5 | ND | ND | 4 | ND | ND | 0.25 | ND | ND | 1–2 | ND | ND | 64 |
| 72 | ND | ND | 0.5–1 | ND | ND | 8 | ND | ND | 0.25 | ND | ND | 2 | ND | ND | 64 | |
| R. minuta (2) | 48 | ND | ND | 0.5 | ND | ND | 2 | ND | ND | 4 | ND | ND | 2 | ND | ND | 64 |
| 72 | ND | ND | 1 | ND | ND | 4 | ND | ND | 4 | ND | ND | 2 | ND | ND | 64 | |
| R. dairenensis (2) | 48 | ND | ND | 0.5–1 | ND | ND | 16 | ND | ND | 0.25–0.5 | ND | ND | 2 | ND | ND | 64 |
| 72 | ND | ND | 0.5–1 | ND | ND | >16 | ND | ND | 0.5–1 | ND | ND | 1–2 | ND | ND | 64 | |
a
AMB, amphotericin B; CAS, caspofungin; VRC, voriconazole; PSC, posaconazole; FLC, fluconazole; ND, not determined.