Table 1.

E. faecium strains, MICs, and genotypes

Strain	Source	Etest MIC (μg/ml)d		YycG change	LiaFSR changec	Reference
		DAP	VAN
S447a	Urine	3	256	No	No	7
R446a	Blood	16	16	Yes	No	7
S447ClsR218Q	Allelic replacement of cls in S447	3	256	No	No	This work
TX0133ab	Blood	3	256	Yes	Yes	21
TX0133a.4	In vitro derivative of TX0133a obtained outside the inhibition zone of a vancomycin Etest strip	3	1	Yes	Yes	21
TX0133a.1	In vitro derivative of TX0133a obtained within the inhibition zone of a vancomycin Etest strip	4	512	No	Yes	21
TX0133bb	Blood after DAP therapy	4	2	No	Yes	21
TX0133cb	Blood after VAN therapy	3	512	No	Yes	21

^aClinical strain pair from a patient who developed urinary tract infection (S447) and bacteremia (R446) (7).

^bClinical strain set of DAP-susceptible isolates from a different patient with E. faecium endocarditis who failed DAP monotherapy (21).

^cS105N substitution in LiaS.

^dDAP, daptomycin; VAN, vancomycin.