Fig 7.

Correlation plots between the Hz inhibition (β-hematin inhibitory activity [BHIA]) IC₅₀ and antiplasmodial activities against HB3 (A, C) or Dd2 (B, D) for a series of CQ analogues. Best-fit plots of the data were generated by the least-squares method using SigmaPlot software. (A) Plot of BHIA IC₅₀ versus antiplasmodial IC₅₀ for CQS HB3 parasites (R² = 0.653); (B) plot of BHIA IC₅₀ versus antiplasmodial IC₅₀ for CQR Dd2 parasites (R² = 0.639); (C) plot of BHIA IC₅₀ versus antiplasmodial LD₅₀ for HB3 parasites (R² = 0.015); (D) plot of BHIA IC₅₀ versus antiplasmodial LD₅₀ for Dd2 parasites (R² = 0.057). IC₅₀ and LD₅₀ values are those found in Table S1 in the supplemental material.