Fig 5.

Analysis of in vivo liver stage activity of P4Q-158 using bioluminescent imaging (BLI). Mice were treated the day before, the day of, and the day following infection with 10,000 Pb1052 Cl1 sporozoites. (A) At 44 h (44HR) postexposure, mice treated with P4Q-158 at 10, 50, and 100 mg/kg had significantly lower infection rates than the untreated mice (Dunnett's multiple-comparison test, P < 0.05). (B) Survival curve analysis showed that mice treated with P4Q-158 had a significantly higher survival rate than the untreated mice (Dunnett's multiple-comparison test, P < 0.05).