Fig 6.

Analysis of in vivo liver stage activity of P4Q-146 using bioluminescent imaging (BLI). Mice were treated the day before, the day of, and the day following infection with 10,000 Pb1052 Cl1 sporozoites. (A) At 44 h (44HR) postexposure, a majority of the mice treated with P4Q-146 had liver stage infections. (B) Survival curve analysis showed that mice treated with 50 mg/kg s.c. of P4Q-146 had the highest survival rate, 40%; however, this was not significantly different from the survival rate of the untreated mice.