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Kaplan-Meyer curves in rats during the course of left-sided pneumonia caused by the WT K. pneumoniae strain (A) or the ESBL-positive K. pneumoniae strain (B). Rats (10 to 12 per group) were treated with ceftazidime starting 24 h after bacterial inoculation of the left lung. Ceftazidime was administered intramuscularly every 12 h with doses of 12.5 mg/kg (▼) or 50 mg/kg (●) for 18 days. Untreated rats (⧫) are also shown. Rat survival rates were monitored daily until 10 days posttreatment.
