Skip to main content
. 2013 Jan;57(1):643–646. doi: 10.1128/AAC.01154-12

Table 1.

Pharmacokinetic parameters after single doses and 5 consecutive doses of tigecycline in ratsa

Treatment regimen AUC (mg · h/liter)
V/F (liters/kg)
CL/F (liters/h)
t1/2α (h)
t1/2β (h)
Estimate SE Estimate SE Estimate SE Estimate SE Estimate SE
6.25 mg/kg 1× 15.71 0.44 1.54 0.18 0.40 0.01 1.19 0.36 6.05 0.54
6.25 mg/kg 5× 16.82 0.94 0.65 0.24 0.37 0.02 0.44 0.19 7.06 0.62
12.5 mg/kg 1× 38.37 0.94 0.78 0.08 0.33 0.01 0.76 0.12 6.14 0.29
12.5 mg/kg 5× 34.29 2.15 0.58 0.15 0.36 0.02 0.40 0.15 6.52 0.60
a

Serum tigecycline levels were determined after administration of tigecycline at 6.25 mg/kg and 12.5 mg/kg in either a single dose (1×) or 5 consecutive doses (5×). Samples for pharmacokinetic analysis were taken (steady state) at 0.25, 0.5, 1, 2, 4, 6, 8, 20, and 24 h after the single administration or after the fifth dose of tigecycline. Concentration-time curves were analyzed using WinNonlin employing a two-compartment model. V, volume of distribution; CL, clearance; t1/2α, half-life at α phase; t1/2β, half-life at β phase; SE, standard error.