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. 2013 Jan;57(1):661–663. doi: 10.1128/AAC.01593-12

Table 1.

MICs and k2/K second-order rate constants

Compound MIC (μg/ml) and PBP2x k2/K (M−1 s−1) (reference) for:
S. pneumoniae R6
 S. pneumoniae 5204
MIC k2/K MIC k2/K
Ceftaroline 0.0125 1 × 106 0.5–0.75 12,600
Cefotaxime <0.016 (18) 100,000 (6) 12 (18) 85 (6)
Penicillin G 0.01–0.05 (11) 110,000 (11) 6.0 (11) 104 (11)