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Results of therapeutic drug monitoring of voriconazole. Shown is the percentage of children reaching normal, subnormal, or supranormal therapeutic Ctroughs (black, light gray, and dark gray boxes, respectively) after the initial recommended or extrapolated dose (a) and after TDM-based (recurrent) dose adjustments (b). The results are divided by age group (<2 years of age, 2 to 12 years of age, and >12 years of age).
