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Amino acid substitutions in NS5A cDNA isolated from DCV-treated HCV3a1 replicon cells
| DCV selection conc (nM) | DCV EC50 (nM) toward selected cellsa | NS5A amino acid substitutionsb |
|---|---|---|
| 0c | 0.47 ± 0.08 | None |
| 10 | >1,000 | L31F (40%), Y93H (60%) |
| 100 | >1,000 | L31F (30%), Y93H (70%) |
Values are means and standard deviations (where applicable) (n ≥ 3).
Values in parentheses are estimates of likelihood deduced from bulk population sequence traces.
DMSO control.
