Table 3.
ST-148 antiviral spectrum of activity and selectivity
| Virus | Family | Genus | Groupc | EC50 (μM) |
|---|---|---|---|---|
| Modoc virus | Flaviviridae | Flavivirus | +ssRNA | 0.36 |
| Yellow fever virusa | Flaviviridae | Flavivirus | +ssRNA | 6.97 |
| Japanese encephalitis virusa | Flaviviridae | Flavivirus | +ssRNA | >50 |
| Bovine viral diarrhea virus | Flaviviridae | Pestivirus | +ssRNA | >50 |
| Hepatitis C virusb | Flaviviridae | Hepacivirus | +ssRNA | 39.2 |
| Sindbis virus | Togaviridae | Alphavirus | +ssRNA | >50 |
| Influenza A virus | Orthomyxoviridae | InfluenzavirusA | −ssRNA | >25 |
| Vaccinia virus | Poxviridae | Orthopoxvirus | dsDNA | >50 |
| Herpes simplex virus 1 | Herpesviridae | Simplexvirus | dsDNA | >50 |
a
In vitro testing done by Integrated Biotherapeutics via a CPE-based assay in Vero cells.
b
In vitro testing done by the Neyts laboratory at the Rega Institute using a subgenomic HCV replicon (genotype 1b) in Huh 5.2 cells (27).
c
ssRNA, single-stranded RNA; dsDNA, double-stranded DNA; +, plus strand; −, minus strand.