Table 4.
Pharmacokinetic parameters of ST-148 in strain 129 micea
| Route | Dose (mg/kg) | Tmax (h) | Cmax (ng/ml) | AUC (h · ng/ml) |
|---|---|---|---|---|
| p.o. | 50 | 1.0 | 3,138 | 5826 |
| i.p. | 50 | 1.0 | 52,283 | 77,011 |
| i.v. | 20 | 0.1 | 41,133 | 25,523 |
Plasma drug concentrations were measured by LC-MS/MS over a 24-h time period. Tmax, time of maximal concentration; Cmax, maximal concentration.