Table 1.

Plasma pharmacokinetics of Bac-ELP-H1. Plasma clearance data following IV injection of rhodamine-labeled Bac-ELP1-H1, with or without tumor heating, were fit to a two compartment pharmacokinetic model.

		Bac-ELP1-H1 (tumor unheated)	Bac-ELP1-H1 (tumor heated)	Bac-ELP2-H1 (tumor unheated)	Bac-ELP2-H1 (tumor heated)
Initial concentration	Co (µg/mL)	140.2 ± 28.9	95.0 ± 26.7	78.9 ± 7.5	81.7 ± 12.5
Central compartment volume of distribution	Vc (mL)	11.1 ± 1.7	15.5 ± 5.3	20.2 ± 2.3	23.2 ± 3.1
Plasma clearance	Cl (mL min−1)	0.16 ± 0.03	0.18 ± 0.05	0.28 ± 0.04	0.32 ± 0.06
Area under curve	AUC (µg min mL−1)	9713.5 ± 1393.9	7752.4 ± 1665.6	5786.1 ± 861.5	6104.4 ± 1135.3
Tissue to plasma rate constant	ktp (min−1)	0.025 ± 0.008	0.047 ± 0.019	0.029 ± 0.004	0.026 ± 0.004
Plasma to tissue rate constant	kpt (min−1)	0.021 ± 0.014	0.032 ± 0.014	0.049 ± 0.017	0.034 ± 0.009
Elimination rate constant	kel (min−1)	0.014 ± 0.003	0.012 ± 0.002	0.014 ± 0.001	0.014 ± 0.002
Distribution half life	t1/2,dist (min)	14.6 ± 4.5	9.4 ± 3.4	8.4 ± 2.0	10.4 ± 1.9
Terminal half life	t1/2,term (min)	102.0 ± 9.2	104.4 ± 15.2	152.7 ± 28.7	136.9 ± 23.0