Table 2.

GSM potency versus plasma exposure in mice.

	E-2012	JNJ-40418677	GSM1	SPI-1810
In vitro Aβ 42 IC50 (nM) CHO-2B7 cells	33	172	62	114
Plasma exposure (μM)	4923	7764	2744	14638
Plasma fold over Aβ 42 IC50 for 25% reduction	149	45	44	128
Brain exposure (μM)	2749	7497	8681	20368
Brain fold over Aβ 42 IC50 for 25% reduction	83	44	140	179