Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Metabolic activation of AA and its reaction with DNA. Adduct formation occurs after reduction of the nitro moiety of the phenanthrene rings of AA-I and AA-II to form the N-hydroxyaristolactams and proposed nitrenium ions, which react with dG and dA to form dA-AL-I, dG-AL-I, dA-AL-II, and dG-AL-II.
