Table 1.
Adducts per 109 bases
|
||||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Target level dA-AL-l | Day 1 | Day 2 | Day 3 | Day 4 | Overall mean | CV(%) within-day | CV(%) between-day | |
3 adducts per 109 bases | Mean | 3.3 | 2.6 | 3.3 | ND | 3.1 | 7.8 | 14.3 |
SD | 0.2 | 0.3 | 0.2 | |||||
RSD(%) | 5.5 | 10.9 | 7.4 | |||||
5 adducts per 109 bases | Mean | 5.6 | 5.0 | 4.7 | ND | 5.1 | 13.8 | 15.2 |
SD | 0.6 | 0.8 | 0.6 | |||||
RSD(%) | 11.1 | 16.4 | 12.9 | |||||
10 adducts per 109 bases | Mean | 11.0 | 8.1 | 8.8 | ND | 9.3 | 14.3 | 20.5 |
SD | 2.1 | 0.7 | 0.6 | |||||
RSD(%) | 19.1 | 8.9 | 6.4 | |||||
50 adducts per 109 bases | Mean | 50.8 | 43.5 | 50.0 | 48.0 | 48.0 | 6.2 | 8.6 |
SD | 1.3 | 4.4 | 1.6 | 3.4 | ||||
RSD(%) | 2.5 | 10.2 | 3.3 | 7.0 | ||||
100 adducts per 109 bases | Mean | 94.5 | 81.8 | 79.3 | ND | 85.2 | 6.2 | 11.2 |
SD | 2.9 | 7.9 | 3.0 | |||||
RSD(%) | 3.1 | 9.7 | 3.8 |
Adducts per 109 bases
|
||||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Target level dG-AL-l | Day 1 | Day 2 | Day 3 | Day 4 | Overall mean | CV(%) within-day | CV(%) between-day | |
20 adducts per 109 bases | Mean | 12.5 | 12.3 | 11.0 | 11.5 | 11.8 | 9.4 | 10.0 |
SD | 0.6 | 0.2 | 1.5 | 0.6 | ||||
RSD(%) | 4.6 | 12.2 | 13.4 | 5.0 | ||||
40 adducts per 109 bases | Mean | 26.0 | 19.0 | 19.3 | ND | 19.8 | 9.8 | 21.6 |
SD | 2.3 | 2.2 | 1.3 | |||||
RSD(%) | 8.9 | 11.4 | 6.5 |
N = 4 analyses per dose
ND, not determined