. Author manuscript; available in PMC: 2013 May 21.

Published in final edited form as: Chem Res Toxicol. 2012 May 4;25(5):1119–1131. doi: 10.1021/tx3000889

Table 2.

dA-AL-I and dG-AL-I Adduct Estimates in Mouse Liver and Kidney: UPLC-ESI/MSⁿ versus ³²P-Postlabeling Measurements

AA-I Dose (mg/kg)	Tissue		dA-AL-I per 10⁸ bases			dG-AL-I per 10⁸ bases
AA-I Dose (mg/kg)	Tissue		UPLC-ESI/MS/MSⁿ	³²P-Postlabeling		UPLC-ESI/MS/MSⁿ	³²P-Postlabeling
0.1	Liver	Avg	52.7	55.1	Avg	19.0	14.6
		SD	7.4		SD	2.8
		CV(%)	14.1		CV(%)	14.6
1.0	Liver	Avg	176	113.0	Avg	58.1	35.7
		SD	3.5		SD	4.6
		CV(%)	2.0		CV(%)	7.9

0.1	Kidney	Avg	43.9	61.6	Avg	22.8	27.1
		SD	3.4		SD	1.8
		CV(%)	7.8		CV(%)	7.7
1.0	Kidney	Avg	1020	717	Avg	300	115
		SD	97.2		SD	10.5
		CV(%)	9.6		CV(%)	3.5

N = 4 independent measurements by UPLC-ESI/MS/MSⁿ