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Production of clavam metabolites. (A) The biosynthetic pathway to clavaminic acid, the branch point intermediate leading to production of clavulanic acid and 5S clavams. Gene designations are shown in italics. (B) Part of the cephamycin-clavulanic acid gene cluster. Cephamycin-specific genes are shown in white, and clavulanic acid-specific genes are shown in gray. Locations of restriction endonuclease cleavage sites relevant to descriptions in the text are shown.
