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UPEC requires functional cAMP-CRP for virulence in the murine urinary tract. Adult female CBA/J mice (A, B) or C3H/HeJ mice (C) were infected via catheterization with 1 × 107 CFU of wild-type UTI89 or isogenic mutants lacking cyaA or crp. Graphs show bacterial titers present in the bladder at 6 h (A) and 3 days (B, C) postinoculation. Bars indicate median values for each group; n ≥ 11 mice. P values were determined using Mann-Whitney U tests.
