Fig 2.

GXM induces regulation of IL-1β, TNF-α, IL-6, and IL-10 production in spleens and sera of endotoxemic mice. Mice were treated with sterile saline or with LPS (0.6 mg/mouse) and/or GXM (100 μg/mouse) 15 min after LPS treatment. IL-1β (A and B), TNF-α (C and D), IL-6 (E and F), and IL-10 (G and H) levels in supernatant fluids from spleens and in sera were determined by enzyme-linked immunosorbent assay (ELISA) 1 h, 6 h, and 24 h after LPS treatment. Values represent the means and SEM for five separate experiments. *, P < 0.05 (LPS-plus-GXM-treated versus LPS-treated mice).